[20] The early-stage research determined the safety and dose level for two vaccine candidates, with the trial expanding during mid-2020 to assess efficacy and safety of BNT162b2 in greater numbers of participants, reaching tens of thousands of people receiving test vaccinations in multiple countries in collaboration with Pfizer and Fosun. [23] An interim analysis of study data showed a potential efficacy of over 90% in preventing infection within seven days of a second dose. Use census records and voter lists to see where families with the Pfizer surname lived. [31] In December 2020, the United Kingdom was the first country to authorize the vaccine on an emergency basis,[27] soon followed by the United States, the European Union and several other countries globally. Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant and anxiolytic medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, and generalized anxiety disorder. [212] The Hong Kong government said it would receive its first batch of one million doses by the first quarter of 2021. It is given by intramuscular injection. ", "From science to syringe: COVID-19 vaccines are miracles of science and supply chains", "Pfizer's Chesterfield workforce playing a key role in coronavirus vaccine development", "A vial, a vaccine and hopes for slowing a pandemic — how a shot comes to be", "Historic journey: Pfizer prepares to deliver 6.4 million doses of COVID-19 vaccines", "Pfizer, Moderna ready vaccine manufacturing networks", "Pfizer expects to cut COVID-19 vaccine production time by close to 50% as production ramps up, efficiencies increase", "BioNTech to Acquire GMP Manufacturing Site to Expand COVID-19 Vaccine Production Capacity in First Half 2021", "Pfizer-BioNTech COVID-19 Vaccine Frequently Asked Questions", "Extra dose from vials of Comirnaty COVID-19 vaccine", "AIFA, possibile ottenere almeno 6 dosi da ogni flaconcino del vaccino BioNTech/Pfizer", "Biden wants to squeeze an extra shot of vaccine out of every Pfizer vial. The original uploader was Vargklo at English Wikipedia. [137], After the United Kingdom, the following countries expedited processes to approve the Pfizer–BioNTech COVID‑19 vaccine for use: Argentina,[138] Australia,[139] Bahrain,[140] Canada,[8][141] Chile,[142] Costa Rica,[143] Ecuador,[142] Hong Kong,[144] Iraq,[145] Israel,[146] Jordan,[147] Kuwait,[148] Malaysia,[149] Mexico,[150] Oman,[151] Panama,[108] the Philippines,[152] Qatar,[153] Saudi Arabia,[35][154] Singapore,[155][156] South Korea,[157][158] the United Arab Emirates,[159] and the United States. Proposed INN: List 124 – COVID-19 (special edition)", "Pfizer and BioNTech Receive Authorization in the European Union for COVID-19 Vaccine", "The inside story behind Pfizer and BioNTech's new vaccine brand name, Comirnaty", "Global Information About Pfizer–BioNTech COVID‑19 Vaccine (also known as BNT162b2)", A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID‑19 in Healthy Individuals, "How the Pfizer-BioNTech Covid-19 Vaccine Works", Cedillo v. Secretary of Health and Human Services, Decentralized Privacy-Preserving Proximity Tracing, Sancaktepe Prof. Dr. Feriha Öz Emergency Hospital, Yeşilköy Prof. Dr. Murat Dilmener Emergency Hospital, NHS Nightingale Hospital Yorkshire and the Humber, Kandakadu Treatment and Rehabilitation Centre, Coalition for Epidemic Preparedness Innovations, International Committee on Taxonomy of Viruses, COVID-19 Response Acceleration Task Force, Great American Economic Revival Industry Groups, Inter-Agency Task Force on Emerging Infectious Diseases, National COVID-19 Commission Advisory Board, Africa Centres for Disease Control and Prevention, Coronavirus Scientific Advisory Board (Turkey), Korea Disease Control and Prevention Agency, Tests, cases, tests per capita, cases per capita by country, Tests, cases, tests per capita, cases per capita by country subdivision, World map by countries: confirmed per capita, https://en.wikipedia.org/w/index.php?title=Pfizer–BioNTech_COVID-19_vaccine&oldid=1013076168, Medical responses to the COVID-19 pandemic, Pages with non-numeric formatnum arguments, CS1 Norwegian Bokmål-language sources (nb), Short description is different from Wikidata, Wikipedia articles needing clarification from January 2021, Infobox drug articles with non-default infobox title, Articles containing unverified chemical infoboxes, Articles which use infobox templates with no data rows, Creative Commons Attribution-ShareAlike License, BNT162b2, COVID-19 mRNA vaccine (nucleoside-modified), This page was last edited on 19 March 2021, at 21:58. Főbb termékei. [186] Over half of the days in the production process are dedicated to rigorous testing and quality assurance at each of the three stages. [20] For approval in the EU, an overall vaccine efficacy of 95% was confirmed by the EMA. It is an RNA vaccine made of nucleoside-modified mRNA which is meant to create spike protein of SARS-CoV-2. Firma secretario de Salud convenio con Pfizer para fabricación y suministro de vacuna COVID-19", "Fosun Pharma to supply Covid-19 vaccine to Hong Kong, Macau once approved", "Hong Kong buys 15 million Covid-19 vaccine doses from Sinovac, Pfizer", "BioNTech and Fosun Pharma to Supply China with mRNA-based COVID-19 Vaccine", "Pfizer Has Offered South Africa Discounted Covid-19 Vaccines", "SA has secured more than 40 million Covid-19 vaccine doses - Ramaphosa", "International Nonproprietary Names for Pharmaceutical Substances (INN). [169] This marked the beginning of mass vaccination in continental Europe. General (2 matching dictionaries) Pfizer, pfizer: Wordnik [home, info] Pfizer: Wikipedia, the Free Encyclopedia [home, info] Slang (1 … "Project Lightspeed", the project to develop a novel mRNA technology for a COVID-19 vaccine, began in mid-January 2020 just days after the SARS-Cov-2 genetic sequence was first made public. The STANDS4 Network ... Wikipedia (0.00 / 0 votes) ... English (English) Word of the Day At Pfizer, we innovate every day to make the world a healthier place. [11], The World Health Organization (WHO) authorized it for emergency use. History 1952–2000. Pfizer, la compagnie pharmaceutique mondialement reconnue. Yrityksen pääkonttori sijaitsee New Yorkissa.Yrityksellä oli noin 90 000 työntekijää vuonna 2018, ja liikevaihdoltaan se on Fortune 500-listan mukaan maailman 61:nneksi suurin yritys. [38][39] Distribution and storage of the vaccine is a logistics challenge because it needs to be stored at extremely low temperatures. Size of this PNG preview of this SVG file: 800 × 327 pixels. The DNA is stored in tiny bottles and frozen for shipment. "[219][220], The vaccine also has the common name "COVID‑19 mRNA vaccine (nucleoside-modified)"[2] and may be distributed in packaging with the name Pfizer–BioNTech COVID‑19 Vaccine. [180] Therefore, all doses administered in the Americas outside of the United States have required at least two transatlantic flights (one to take DNA to Europe and one to bring back finished vaccine vials). [186], BioNTech announced in September 2020, that it had signed an agreement to acquire from Novartis a manufacturing facility in Marburg, Germany, to expand their vaccine production capacity. [19][62] In these Phase I studies, BNT162b2 was shown to have a better safety profile than the other three BioNTech candidates. [2] Deutsche Niederlassungen befinden sich in Karlsruhe und Freiburg. The Initial Pivotal Phase II / III Trial with the lead vaccine candidate 'BNT162b2' began in July. [67], Severe allergic reaction has been observed in approximately 11 cases per million doses of vaccine administered. Attribution: Arne Müseler / www.arne-mueseler.com You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. [163][189] The Italian Medicines Agency officially authorized the use of excess doses remaining within single vials. It is ranked the largest drug company in the world. [28] In a report published on 4 March 2021 it concluded that "the benefits of Comirnaty in preventing COVID-19 continue to outweigh any risks, and there are no recommended changes regarding the use of this vaccine. One of the world's largest pharmaceutical companies, it is ranked 64 on the 2020 Fortune 500 list of the largest United States corporations by total revenue. The site will be the third BioNTech facility in Europe which currently produces the vaccine, while Pfizer operates at least four production sites in the United States and Europe. The first stage involves the molecular cloning of DNA plasmids that code for the spike protein by infusing them into Escherichia coli bacteria. [180], The Pfizer plant in Puurs is responsible for all vials for destinations outside the United States. [201][202], Pfizer indicated in its 9 November press release that 50 million doses could be available by the end of 2020, with about 1.3 billion doses provided globally by 2021. From scientific discovery to breakthrough products to our essential partnerships around the world, we’re committed to … In 1880 there were 11 Pfizer families living in New York. [214], In January 2021, Pfizer and BioNTech offered to supply 50 million doses of COVID‑19 vaccine for health workers across Africa between March and the end of 2021, at a discounted price of US$10 per dose. The Pfizer–BioNTech COVID‑19 vaccine (pINN: tozinameran), sold under the brand name Comirnaty, is an mRNA based COVID-19 vaccine. [164][165], On 16 February 2021, the South African Health Products Regulatory Authority (SAHPRA) in South Africa issues Section 21, Emergency Use Approval for the vaccine. [55] The EMA clarified that the second dose should be administered three weeks after the first dose. Pfizer's history starts in 1849 with founder Pfizer & Erhart cousins who started their NY office, laboratory, factory, and warehouse. [49], In June 2020, BioNTech received €100 million (US$119 million) in financing from the European Commission and European Investment Bank. [177][178][179] On 12 December, the Canadian regulator followed suit, noting that: "Both individuals in the U.K. had a history of severe allergic reactions and carried adrenaline auto injectors. Login . The production of the vaccine was followed by clinical trials, the success of which was a prerequisite for the commencement of marketing. [40], Before COVID-19 vaccines, a vaccine for an infectious disease had never before been produced in less than several years, and no vaccine existed for preventing a coronavirus infection in humans. After four days of growth, the bacteria are killed and broken open, and the contents of their cells are purified over a week and a half to recover the desired DNA product. For all markets, this stage is conducted in the United States,[180] at a small Pfizer pilot plant in Chesterfield, Missouri[181] (near St. Louis). [174], The adverse effect profile of the Pfizer–BioNTech COVID‑19 vaccine is similar to that of other adult vaccines. [2] Företaget har 80 000 medarbetare och finns i fler än 150 länder. [163] According to the vial labels, each vial contains five 0.3 ml doses, however excess vaccine may be used for one, or possibly two, additional doses. [136] By 20 December, 521,594 UK residents had received the vaccine as part of the national vaccination programme. [187], The vaccine is being delivered in vials that, once diluted, contain 2.25 ml of vaccine (0.45 ml frozen plus 1.8ml diluent). [46][47], BioNTech started its program 'Project Lightspeed' to develop a vaccine against the new COVID‑19 virus based on its already established mRNA-technology. [50] In September 2020, the German government granted BioNTech €375 million (US$445 million) for its COVID‑19 vaccine development program. : Pfizer, the world's largest research-based pharmaceutical company. 辉瑞公司（英語： Pfizer, Inc. ， / ˈ f aɪ z ər / ），是一家总部位于美国 纽约的跨国制药、生物技術公司，研发总部位于康涅狄格州的格罗顿市。 根据收入排名，辉瑞是全球最大的制药公司。 輝瑞公司的股票於2004年4月8日成為道瓊斯工業指數的成份股。 They both were treated and have recovered. The German company BioNTech is the initial developer of the vaccine, and partnered with American company Pfizer for support with the clinical trials, logistics and manufacturing. [63] The sequence contains no uridine residues; they are replaced by 1-methyl-3'-pseudouridylyl. [22][37], The Phase III trial assesses the safety, efficacy, tolerability, and immunogenicity of BNT162b2 at a mid-dose level (two injections separated by 21 days) in three age groups: 12–15 years, 16–55 years or above 55 years. The Pfizer–BioNTech COVID‑19 vaccine (pINN: tozinameran), sold under the brand name Comirnaty,[15] is an mRNA based COVID-19 vaccine. Argentina - Español Australia - English Austria - Deutsch. : L'engagement et les domaines de recherche prioritaires de Pfizer seront confirmés au début de 2006.: Pfizer's commitment and areas of research priority will be confirmed in early 2006.: Chaque comprimé porte le logo Pfizer sur une face. We found 3 dictionaries with English definitions that include the word pfizer: Click on the first link on a line below to go directly to a page where "pfizer" is defined. [195][196] In February 2021, the U.S. Food and Drug Administration (FDA) updated the emergency use authorization (EUA) to permit undiluted frozen vials of the vaccine to be transported and stored at between −25 and −15 °C (−13 and 5 °F) for up to two weeks before use. [59] The study will evaluate 30 µg of BNT162b2 or placebo administered via intramuscular injection in 2 doses, 21 days apart. Similarly, India's existing cold chain network can only handle temperatures between 2 and 8 °C (36 and 46 °F), far above the requirements of the vaccine. [182] At this stage, it takes only four days to go from mRNA and lipids to finished vials, but each lot must then spend several weeks in deep-freeze storage while undergoing verification against 40 quality-control measures. În 2012, a fost una dintre cele mai mari companii farmaceutice din lume și s-a clasat pe locul 57 pe lista Fortune 500 din 2018 a celor mai mari corporații din SUA după venituri totale. History. [20] It is a "randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals". [186] Pfizer also revealed that the process requires 280 components and relies upon 25 suppliers located in 19 different countries. Pfizer buildings on spit of land known as Bloody Point - geograph.org.uk - 1586955.jpg 640 × 480; 211 KB Pfizer Diesel Switcher from old Reading car @ DRM.jpg 3,648 × 2,736; 2.07 MB Pfizer Finland HQ February 13 2009.jpg 4,088 × 2,714; 5.08 MB Pfizer is known for its drugs Advil and ChapStick. Pfizer Inc. engages in the discovery, development, and manufacture of healthcare products specializes in medicines, vaccine, and consumer healthcare. Pfizer acquired an 80-acre site on the outskirts of Sandwich in 1954 to enable the expansion of its Kent-based activities. [18][37], Manufacturing the vaccine requires a three-stage process. [180] Once the mRNA has been created and purified, it is frozen in plastic bags about the size of a large shopping bag, of which each can hold up to 5 to 10 million doses. [39] The vaccine needs to be stored and transported at ultracold temperatures between −80 and −60 °C (−112 and −76 °F),[40][58][39][199][200] much lower than for the similar Moderna vaccine. [63] It consists of a five-prime cap; a five prime untranslated region derived from the sequence of human alpha globin; a signal peptide (bases 55–102) and two proline substitutions (K986P and V987P, designated "2P") that cause the spike to adopt a prefusion-stabilized conformation reducing the membrane fusion ability, increasing expression and stimulating neutralizing antibodies;[19][64] a codon-optimized gene of the full-length spike protein of SARS-CoV-2 (bases 103–3879); followed by a three prime untranslated region (bases 3880–4174) combined from AES and mtRNR1 selected for increased protein expression and mRNA stability[65] and a poly(A) tail comprising 30 adenosine residues, a 10-nucleotide linker sequence, and 70 other adenosine residues (bases 4175–4284). [19] The vaccination requires two doses given three weeks apart. [37] Pfizer has advanced purchase agreements of about US$3 billion for providing a licensed vaccine in the United States, the European Union, the United Kingdom, Japan, Canada, Peru, Singapore, and Mexico. [1][168] On 23 December, a Lucerne resident, a 90-year-old woman, became the first person to receive the vaccine in Switzerland. Pfizer, Inc. (/ ˈ f aɪ z ər /) este o corporație farmaceutică americană cu sediul în New York City. [12][13] It must be thawed to room temperature and diluted with normal saline before administration. It does not meet the threshold of originality needed for copyright protection, and is therefore in the public domain. The vaccine is given by injection. The company bought Wyeth, which also used to be a drug company. It won't be easy", "Recommendation for an Emergency Use Listing of Tozinameran (Covid-19 Mrna Vaccine (Nucleoside Modified)) Submitted by Biontech Manufacturing Gmbh", "Australian Product Information – Comirnaty (BNT162b2 [mRNA]) COVID-19 Vaccine", "Coronavirus (COVID-19) Update: FDA Allows More Flexible Storage, Transportation Conditions for Pfizer-BioNTech COVID-19 Vaccine", "Pfizer and BioNTech Submit COVID-19 Vaccine Stability Data at Standard Freezer Temperature to the U.S. FDA", "Pfizer and BioNTech's vaccine poses global logistics challenge", "Daunting task of distribution exposed as it emerges some vaccines must be 'deep frozen' at −70C", "How China's COVID-19 could fill the gaps left by Pfizer, Moderna, AstraZeneca", "Pfizer's Vaccine Is Out of the Question as Indonesia Lacks Refrigerators: State Pharma Boss", "U.S. to pay Pfizer, BioNTech $1.95 bln for millions of COVID-19 vaccine doses", "U.S. Government Engages Pfizer to Produce Millions of Doses of COVID-19 Vaccine", "So is Pfizer part of Operation Warp Speed or not? ALC-0159 is a polyethylene glycol conjugate (that is, a PEGylated lipid). The bags are placed on special racks on trucks which take them to the next plant. Every effort should be made to determine which vaccine product was received as the first dose. [52], Phase I / II Trials were started in Germany on 23 April 2020, and in the U.S. on 4 May 2020, with four vaccine candidates entering clinical testing. For other vaccination topics, see, A vial of the Pfizer–BioNTech COVID‑19 vaccine, US authorization also includes the three sovereign nations in the, Chinese Center for Disease Control and Prevention, COVID-19 vaccine § Clinical trials started in 2020, National Institute of Allergy and Infectious Diseases, 1,2-distearoyl-sn-glycero-3-phosphocholine, Medicines and Healthcare products Regulatory Agency, Centers for Disease Control and Prevention, Advisory Committee on Immunization Practices, Swiss Agency for Therapeutic Products (Swissmedic), Committee for Medicinal Products for Human Use, "Swissmedic grants authorisation for the first COVID-19 vaccine in Switzerland", "Comirnaty (BNT162b2 [mRNA]) COVID‑19 Vaccine Product Information", Australian Public Assessment Report for BNT162b2 (mRNA), "Regulatory Decision Summary – Pfizer-BioNTech COVID-19 Vaccine", "Pfizer-BioNTech COVID-19 Vaccine (tozinameran)", "Information for Healthcare Professionals on Pfizer/BioNTech COVID-19 vaccine", "Conditions of Authorisation for Pfizer/BioNTech COVID-19 vaccine", "FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine", "Pfizer-BioNTech COVID-19 Vaccine- rna ingredient bnt-162b2 injection, suspension", Pfizer-BioNTech COVID-19 Vaccine Emergency Use Authorization Review Memorandum, "Pfizer-BioNTech COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 16 Years of Age and Older", "mRNA vaccines to address the COVID-19 pandemic", "What you need to know about BioNTech – the European company behind Pfizer's Covid-19 vaccine", "Pfizer's early data shows vaccine is more than 90% effective", "Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates", "Pfizer says experimental COVID-19 vaccine is more than 90% effective", "Covid-19 vaccine from Pfizer and BioNTech is strongly effective, early data from large trial indicate", "Update on our COVID-19 vaccine development program with BNT162b2", "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "Questions and Answers About Pfizer-BioNTech COVID-19 Vaccine", "UK medicines regulator gives approval for first UK COVID-19 vaccine", "UK approves Pfizer/BioNTech Covid vaccine for rollout next week", "EMA recommends first COVID-19 vaccine for authorisation in the EU", "Bahrain becomes second country to approve Pfizer COVID-19 vaccine", "Coronavirus: Saudi Arabia approves Pfizer COVID-19 vaccine for use", "Mexico approves emergency use of Pfizer's COVID-19 vaccine", "F.D.A. The Phase III portion of this study will assess the safety, tolerability, and immunogenicity of BNT162b2 or placebo among pregnant women enrolled at 24 to 34 weeks' gestation. [51], Pfizer CEO Albert Bourla stated that he decided against taking funding from the US government's Operation Warp Speed for the development of the vaccine "because I wanted to liberate our scientists [from] any bureaucracy that comes with having to give reports and agree how we are going to spend the money in parallel or together, etc." It became the first COVID-19 vaccine to receive definitive registration rather than emergency use authorization in the country. To satisfy regulations then in place in the United Kingdom on the importation of medicines, Pfizer established a compounding operation in Folkestone, Kent, in the Autumn of 1952. Pfizer is one of the world's premier research-based biopharmaceutical companies. This page was last changed on 15 February 2021, at 18:49. This is the first authorization under a standard procedure. [61], The vaccine candidate BNT162b2 was chosen as the most promising among three others with similar technology developed by BioNTech. [20][21][22] It is one of the two RNA vaccines deployed against COVID‑19 in 2020, the other being the Moderna COVID‑19 vaccine. [161] Following the EUA issuance, BioNTech and Pfizer are expected to continue the Phase III clinical trial to finalize safety and efficacy data, leading to application for licensure (approval) of the vaccine in the United States. [175][176] According to a report by the US Centers for Disease Control and Prevention 71% of those allergic reactions happened within 15 minutes of vaccination and mostly (81%) among people with a documented history of allergies or allergic reactions. [171][173], On February 23, 2021, the Brazilian Health Regulatory Agency approved the Pfizer–BioNTech COVID-19 vaccine under its standard marketing authorization procedure. [3] Sua sede de pesquisa e desenvolvimento encontra-se em Groton, Connecticut, e é uma das maiores empresas farmacêuticas do mundo. [64], In addition to the mRNA molecule, the vaccine contains the following inactive ingredients (excipients):[66][67][9], The first four of these are lipids. [190] As of 8 January 2021, each vial contains six doses. Yes and no", "EU agrees to buy 300 million doses of the Pfizer/BioNTech Covid-19 vaccine", "Japan and Pfizer reach COVID-19 vaccine deal to treat 60 million people", "Trudeau says promising new Pfizer vaccine could be 'light at the end of the tunnel, "Pfizer and BioNTech to Supply Singapore with their BNT162b2 mRNA-based Vaccine Candidate to Combat COVID-19", "233. One of the world's largest pharmaceutical companies, it is ranked 64 on the 2020 Fortune 500 list of the largest United States corporations by total revenue. This stage involves combining the mRNA with lipid nanoparticles, then filling vials, boxing vials, and freezing them. [130] It was the first COVID‑19 vaccine to be approved for national use after undergoing large scale trials,[131] and the first mRNA vaccine to be authorized for use in humans. [22] During clinical trials, the side effects deemed very common[a] are (in order of frequency): pain and swelling at the injection site, tiredness, headache, muscle aches, chills, joint pain, and fever. [163][197][198], Even high-income countries have limited cold chain capacity for ultracold transport and storage of a vaccine that degrades within five days when thawed, and requires two shots three weeks apart. [182], The second stage is being conducted at a Pfizer plant in Andover, Massachusetts[183] in the United States, and at BioNTech's plants in Germany. [187] Once fully operational, the facility would produce up to 750 million doses per year, or over 60 million doses per month. [23], Preliminary results from Phase I–II clinical trials on BNT162b2, published in October 2020, indicated potential for its efficacy and safety. Incorporated 50 years later the company grew to its current size with many acquisitions, mergers and a handful of CEOs. Size of this PNG preview of this SVG file: 800 × 479 pixels. [68], The vaccine is supplied in a multidose vial as "a white to off-white, sterile, preservative-free, frozen suspension for intramuscular injection". [180], In February 2021, Pfizer revealed that the entire sequence initially took about 110 days on average from start to finish, and that the company was making progress on reducing that number to 60 days. Read the full history here. "[66], The European Medicines Agency regularly reviews the data on the vaccine's safety. [135] In a notable example of museums documenting the pandemic, the vial and syringe used for that first dose were saved and acquired by The Science Museum in London for its permanent collection. The deal was completed in 2009. [166][167], On 19 December 2020, the Swiss Agency for Therapeutic Products (Swissmedic) approved the Pfizer–BioNTech COVID‑19 vaccine for regular use, two months after receiving the application, stating that the vaccine fully complied with the requirements of safety, efficacy and quality. Pfizer is named after German-American cousins Charles Pfizer and Charles Erhart (originally from Ludwigsburg, Germany) who launched a fine chemicals business, Charles Pfizer and Company, from a building at the intersection of Harrison Avenue and Bartlett Street [8] in Williamsburg, Brooklyn in 1849. [213], BioNTech and Fosun agreed to supply Mainland China with a batch of 100 million doses in 2021, subject to regulatory approval. A Pfizer Inc. multinacionális gyógyszergyár, amelynek székhelye New Yorkban, az Amerikai Egyesült Államok területén található. [29][132] The United Kingdom thus became the first Western country to approve a COVID‑19 vaccine for national use,[133] although the decision to fast-track the vaccine was criticised by some experts. Am Produktionsstandort in Orth/Donau sind rund 230 Mitarbeiter in der Pfizer Manufacturin… From Simple English Wikipedia, the free encyclopedia, "Financial Review - Pfizer Inc. and Subsidiary Companies", "Pfizer moves higher amid persistent breakup talk", "Fortune 500 Companies 2018: Who Made the List", https://simple.wikipedia.org/w/index.php?title=Pfizer&oldid=7381345, Companies listed on the New York Stock Exchange, Pages with non-numeric formatnum arguments, Wikipedia articles with WorldCat identifiers, Creative Commons Attribution/Share-Alike License. Die Firmenzentrale wurde 2008 von Karlsruhe nach Berlin verlegt. [180] The DNA is used as a template to build the desired mRNA strands,[182] which takes about four days. This was 100% of all the recorded Pfizer's in the USA. [193], The vaccine needs to be stored at temperatures between −80 and −60 °C (−112 and −76 °F),[40] until five days before vaccination[39][40] when it can be stored at 2 to 8 °C (36 to 46 °F), and up to two hours at temperatures up to 25 °C (77 °F)[194][12] or 30 °C (86 °F). The head of Indonesia's Bio Farma Honesti Basyir stated that purchasing the vaccine is out of the question for the world's fourth-most populous country, given that it did not have the necessary cold chain capability. There, they produced an antiparasitic called santonin. Pfizer Inc., är ett amerikanskt multinationellt läkemedelsföretag med huvudkontor i New York som genom köpet av Pharmacia år 2003 blev världens största företag inom läkemedelsindustrin. The company is responsible for the first COVID-19 vaccination. Pfizer and BioNTech announced on 18 February 2021 that the first participants received their first dose in this trial. [185] As of November 2020, the major bottleneck in the manufacturing process was combining mRNA with lipid nanoparticles. [27][28] Monitoring of the primary outcomes from the trials will continue until August 2021, while monitoring of the secondary outcomes will continue until January 2023. Clinical trials began in April 2020; by November the vaccine entered phase III clinical trials, based on more than 40,000 people. [182] Croda International subsidiary Avanti Polar Lipids is providing the requisite lipids. Mikael Dolsten is Pres:Worldwide Research & Dev/Chief Scientific Ofcr at Pfizer Inc. See Mikael Dolsten's compensation, career history, education, & memberships. [63] The 2P proline substitutions in the spike proteins were originally developed for a MERS vaccine by researchers at the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center, Scripps Research, and Jason McLellan’s team (currently at the University of Texas at Austin, previously at Dartmouth College). Erhart died in 1891, and Pfizer in 1906, leaving a company of around 200 employees in the hands of Emil Pfizer, who served as president until the 1940s, the last member of the Pfizer … The most Pfizer families were found in the USA in 1880. It was founded in 1849 in New York City. New York had the highest population of Pfizer families in 1880.
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